Antipsychotic dose and diminished neural modulation: A multi-site fMRI study

Variance Components Analysis of a Multi-Site fMRI Study

Municipal Waste Landfill Site Selection based on Environmental, Geological and Geotechnical Multi-criteria: A Case Study

Waste management is a complex and detailed process that involves evaluation of certain important factors, such as a geological, geotechnical, hydrological, hydrogeological, climate, urban management, environmental, along with social, cultural, and psychological parameters. Unfortunately, in Iran, there is minimal evaluation of initial parameters and in some cases even don’t exist. The purpose o...

A multi-site resting state fMRI study on the amplitude of low frequency fluctuations in schizophrenia

BACKGROUND This multi-site study compares resting state fMRI amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF) between patients with schizophrenia (SZ) and healthy controls (HC). METHODS Eyes-closed resting fMRI scans (5:38 min; n = 306, 146 SZ) were collected from 6 Siemens 3T scanners and one GE 3T scanner. Imaging data were pre-processed using an SPM pipeline. Powe...

A hierarchical modeling approach to data analysis and study design in a multi-site experimental fMRI study.

We propose a hierarchical Bayesian model for analyzing multi-site experimental fMRI studies. Our method takes the hierarchical structure of the data (subjects are nested within sites, and there are multiple observations per subject) into account and allows for modeling between-site variation. Using posterior predictive model checking and model selection based on the deviance information criteri...

High-dose antipsychotic medication.

The dopamine hypothesis for the mode of action of antipsychotic drugs has been with us for some 30 years and has, by and large, withstood the test of time. It simply states that antipsychotic drugs owe their therapeutic effects to an ability to block central dopamine receptors. This has given us a working and testable explanation for the effects of these drugs and it has prompted the synthesis ...